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academic article from descriptive documents, analyzed by collecting data from the Holy Al-Quran, Al-Hadith and views of Muslim scholars. From the study found that Guidelines for enhancing well-being for quality of life, is the existence of religious doctrines by obeying the commands and abandoning all the prohibitions. Those begin with the pursuit of sustenance by honest and religious occupations, make the happy mind by conducting religious activities regularly, and hope more to the quality of life with awareness of consumption, maintaining physical and mental health, exercises, knowing how to treat as being sick, and public health in order to create complete well-being. Therefore, the well-being according to the guidelines of the messenger of Islam (Muhammad) is necessary for humanity or Muslim as believers. That must be adapted to use in life in accordance with the rapidly changes of social conditions in order to benefit from the principles, teachings, and examples of the Prophet Muhammad (SAW), for strengthening well-being both physically and mentally including a pure spirit to the stability, truly wealth and sustainable.