EFFICACY OF TOPICAL DIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE 4% IN NECK WRINKLE REDUCTION

Abstract

This study is aimed to determine the efficacy of Dipeptide Diaminobutyroyl Benzylamide Diacetate 4% cream in treatment of neck wrinkles. The study is conducted by apllying Dipeptide Daminobutyroyl Benzylamide Diacetate 4% cream to 20 volunteers, age between 30-50 years who have neck wrinkles lecel II-III. Cream should be applied twice daily in the morning and evening for 8 weeks, clinical assessment compares skin moisture level, flexibility, wrinkle level and side effect, between before and after cream application, the comparison assessment is done every 2 weeks, while satisfaction assessment is done on 8^th week. Upon the end of the study, it is found that Dipeptide Diaminobutyroyl Benzylamide Diacetate 4% cream can significantly increase skin moisture level in 8^th week (from 54.76 ± 8.43 to 59.38 ± 11.20, p = 0.021) of study period, and also significantly increase skin flexibility, from 0.82 ± 0.04 before study, in 2^nd week (0.85 ± 0.04, p = 0.005), 6^th week (0.85 ± 0.03, p = 0.015) and 8^th week (0.86 ± 0.04, p = 0.001). After 6 weeks of application, the mean of neck wrinkles has been increased to the highest level in 4^th week and began to decrease in 6^th week, then decrease continuously to the point where wrinkles level becomes lower than before conducting the study. For side effects, there is no obvious side effect from cream application. Therefore, the conclusion is Dipeptide Diaminobutyroyl Benzylamide Diacetate 4% cream can increase skin moisture and flexibility level in neck area.